Research & technology

Research, both clinical and technological, is the heart and soul of Nanomedic Technologies. Our team is actively involved in technological research and clinical trials at various European and Israeli hospitals. Nanomedic’s research portfolio is broad and is intended to provide innovative solutions for the field of wound care. Our research is focused on developing nanofibrous layers suitable for treating many types of wounds. The team has many years of expertise and competency in the electrospinning of polymers, chemistry and materials, and the development of medical devices from idea to product.

From a scientific perspective, we focus on burns and acute wound care in all its forms and together with our research teams, physicians, and KOL’s, push the envelope to shift the accepted paradigm in wound care. Through this research, we have re-visited areas that were known to be difficult to dress, like faces, hands, and feet, and introduced the new Spincare paradigm which has started to “make hard, easy” for patients and physicians.

A human hair relative to nanofibers

Portable Electrospinning Technology

Nanomedic is a pioneer in the development of medical devices made of electrospun nano-fabrics with high expertise in the electrospinning technology. Nanomedic’s unique approach to clinical needs such as the wound care space, led to the development of the first and only worldwide commercialized portable electrospinning device. The Spincare Wound Care System, is the only system that integrates electrospinning technology into a portable, bedside device, offering immediate wound care treatment, creating a fully personalized single application customized nano-fibrous transient skin-like layer based on patient’s wound condition, size and contour. This portable technology enhances the inherent characteristics of the electrospun nanofibers, mimicking the structure of the body tissue, providing an excellent medium for tissue integration and regeneration and facilitating the body healing process. Electrospinning is a unique technique that uses electrostatic forces to produce nano-diameter, non-woven fibers that incorporate very fine pore sizes with high surface area, making them an ideal solution for delivering wound healing therapies to any surface of the body.

A human hair on nanofibers

Make hard, easy

From a scientific perspective, we focus on burns and acute wound care in all its forms and together with our research teams, physicians, and KOL’s, push the envelope to shift the accepted paradigm in wound care. Through this research, we have re-visited areas that were known to be difficult to dress, like faces, hands, feet, and groin and introduced the new Spincare paradigm which has started to “make hard, easy” for the physicians. Our accomplishments have been well received by patients and clinical staff alike and we are committed to going even further.

Clinical case studies

Donor Site Wounds

A good healing process of the wound was demonstrated. The Spincare transient skin-like layer served as a temporary skin and supported wound epithelialization underneath within 14 days.

Partial Thickness Burns

Medium size burn wounds on relatively complex body contour are easily treated with Spincare offering both patient and caregiver a rapid and minimally painful option for treatment, resulting in a quick and effective healing process. The advantage of a no-touch transient skin-like layer is demonstrated here not only in preventing infections but also in reducing dressing associated pain. The transparency of the Spincare layer enables good follow up of the healing process.

Publications and general articles

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The Feasibility of a Handheld Electrospinning Device for the Application of Nanofibrous Wound Dressings

The aim of this study was to determine the feasibility of a portable electrospinning device for the application of wound dressings.

Used on partial thickness wounds, polymer electrospun nanofiber dressings provide excellent surface topography and are a nontouch, feasible, and safe method to promote wound healing with the potential to reduce wound infections. Such custom-made nanofibrous dressings have implications for the reduction of pain and trauma, number of dressing changes, scarring, and an added cost benefit.

Haik, J., Kornhaber, R., Blal, B., & Harats, M. (2017). The feasibility of a handheld electrospinning device for the application of nanofibrous wound dressings. Advances in wound care, 6(5), 166-174.

Bioactive Nanofibres for Wound Healing Applications

Electrospun nanofibres have become an exciting area in textile product development, due to their unique properties such as high surface area and porosity. Indeed, many studies on nanofibres have demonstrated
their feasibility in various applications. For example, nanofibre scaffolds were shown to be promoters for tissue cell adhesion and encapsulators for drugs. In the past decade, numerous studies revealed the areas in which nanofibres can be useful, and capability for scaling-up nanofibre production, which established a starting step in the development of a new generation of textile products. However, many challenges faced today are complicated in nature and require a multidimensional approach to solve, necessitating multifunctional products. This review explored recent efforts in developing a new class of active textiles for wound care. The wound care sector is one of the most advanced in the medical industry, with a massive global demand from patients suffering from wounds, burns, and diseases such as diabetes.
Ensuring satisfactory wound healing is often difficult due to the dynamic nature of the skin, requiring fulfilment of multiple objectives at different stages of the healing process. We demonstrated that by controlling how wound dressing release therapeutic agents, its mechanical responses to the wound and
in aqueous environment, a wound dressing that can interact with different wounds can be developed.

Leung, V., Hartwell, R., Yang, H., Ghahary, A., & Ko, F. (2011). Bioactive nanofibres for wound healing applications. Journal of Fiber Bioengineering and Informatics4(1), 1-14.

A review on wound dressings with an emphasis on electrospun nanofibrous polymeric bandages

Wound dressings have experienced continuous and significant changes since the ancient times. The development starts with the use of natural materials to simply cover the wounds to the materials of the present time that
could be specially made to exhibit various extraordinary functions. The modern bandage materials made of electrospun biopolymers contain various active compounds that are beneficial to the healing of wounds.
These materials are fibrous in nature, with the size of fibers segments ranging from tens of nanometers to micrometers. With the right choices of biopolymers used for these fibrous materials, they could enhance the healing
of wounds significantly compared with the conventional fibrous dressing materials, such as gauze. These bandages could be made such that they contain bioactive ingredients, such as antimicrobial, antibacterial, and antiinflammatory agents, which could be released to the wounds enhancing their healing. In an active wound dressing (AWD), the main purpose is to control the biochemical states of a wound in order to aid its healing process. This review provides an overview of different types of wounds, effective parameters in wound healing and different types of wound dressing materials with a special emphasis paid to those prepared by electrospinning.

Zahedi, P., Rezaeian, I., Ranaei‐Siadat, S. O., Jafari, S. H., & Supaphol, P. (2010). A review on wound dressings with an emphasis on electrospun nanofibrous polymeric bandages. Polymers for Advanced Technologies21(2), 77-95.

Advanced Therapeutic Dressings for Effective Wound Healing

Advanced therapeutic dressings that take active part in wound healing to achieve rapid and complete healing of chronic wounds is of current research interest. There is a desire for novel strategies to achieve expeditious wound healing because of the enormous financial burden worldwide. This paper reviews the current state of wound healing and wound management products, with emphasis on the demand for more advanced forms of wound therapy and some of the current challenges and driving forces behind this demand. The
paper reviews information mainly from peer-reviewed literature and other publicly available sources such as the US FDA. A major focus is the treatment of chronic wounds including amputations, diabetic and leg ulcers, pressure sores, and surgical and traumatic wounds (e.g., accidents and burns) where patient immunity is low and the risk of infections and complications are high. The main dressings include medicated moist dressings, tissue-engineered substitutes, biomaterials-based biological dressings, biological and naturally derived dressings, medicated sutures, and various combinations of the above classes. Finally, the review briefly discusses possible prospects of advanced wound healing including some of the emerging physical approaches such as hyperbaric oxygen, negative pressure wound therapy and laser wound healing, in routine clinical care.

Boateng, J., & Catanzano, O. (2015). Advanced therapeutic dressings for effective wound healing—a review. Journal of pharmaceutical sciences104(11), 3653-3680.

Electrospun Antibacterial Nanofibers: Production, Activity, and In Vivo Applications

Electrospinning is an economical and relatively simple method to produce continuous and uniform nanofibers from almost any synthetic and many natural polymers. Because of the high specific surface area, tunable pore size, and flexibility, the nanofibrous membranes are finding an increasingly wide range of applications. Some particular attention has been devoted to antibacterial nanofibers for applications such as wound dressings. A variety of biocides, e.g., antibiotics, quaternary ammonium salts, triclosan, biguanides, (silver, titanium dioxide, and zinc oxide) nanoparticles and chitosan have been incorporated by various techniques into nanofibers that exhibit strong antibacterial activity in standard assays. However, the small diameters of the nanofibers also mean that the incorporated biocides are often burst released once the materials are submerged in an aqueous solution. Nevertheless, several strategies, such as core‐sheath structure of the nanofiber, covalent bonding of the biocide on the fiber surface and adsorption of the biocide in nanostructures, can be utilized to sustain the release over several days. This review summarizes recent development in the fabrication of antibacterial nanofibers, the release profiles of the biocides and their applications in in vivo systems.

Gao, Y., Bach Truong, Y., Zhu, Y., & Louis Kyratzis, I. (2014). Electrospun antibacterial nanofibers: Production, activity, and in vivo applications. Journal of Applied Polymer Science131(18).

This project was sponsored by the European Commission H2020 SME grant 671970